Who took a shit in your pillow case?

exp.

Heard in Waterford

A question asked if someone feels you are unhappy, troubled or angry due to something another person has said or done.

In use

OMG, will you just leave me alone?!" "Jaysus! Who took a shit in your pillow case?!...

Posh English

Good heavens, whatever has upset your equilibrium so profoundly?